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Our group scientific studies bacterial cell division and is aiming to constitute a ‘base up biology’ in artificial cells that could autonomously divide. Our major fascination lies in cell division, chromatin structure, and spatial Command.
Dynamics of initiation, termination and reinitiation of DNA translocation through the motor protein EcoR124I
Non-equilibrium folding of person DNA molecules recaptured as much as a thousand instances inside a sound point out nanopore
We produce level-of-care diagnostics exam of neglected tropical disorders in useful resource-constrained settings, determined by Crspr/Cas9 detecting of pathogen’s DNA in physique fluids.
While in the several years adhering to these discoveries, my analysis interests shifted to biophysics and nanobiology, And that i turned considerably less involved with the development of nanotube electronics. The focus of numerous scientists in the sector also shifted to graphene (in which, funnily sufficient, the first graphene ribbons were being referred to as ‘nanotubes which can be Reduce open up alongside their length’) after the invention of the two-dimensional material in 2004.
MATLAB codes for details processing are available at . Julia codes useful for numerical simulation can be obtained at .
2000, discovery that nanotubes can carry extraordinary massive latest densities; fixed the controversial situation ceesdekker.net of electronic transportation via DNA molecules by measurements of insulating habits at The one molecule degree; and demonstration of the AFM system for one-molecule manipulation of nanotubes
Imagine if, in lieu of employing standard major-down silicon electronics, transistors may be constructed from The underside up utilizing one natural molecules given that the switching factors? This concept, which became The premise of now’s discipline of molecular electronics, first emerged while in the 1970s.
Pretty awesome, but that wasn’t seriously exactly where my fascination lay. I wanted to pioneer and I experienced the feeling that was no more possible, since the most attention-grabbing basic insights experienced now been uncovered. But my area experienced made numerous enjoyable new applications to measure personal molecules. I made a decision that I desired to implement this to biology, to have a look at it from the physical perspective.’
Case in point (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in grey, the rim of your pore is highlighted in purple, and also a 3D rendering with the movement of your DNA rod is exhibited.
1999, initially measurement of your wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for any new Luttinger description of interacting electrons in nanotubes
2005, discovery with the system of DNA uncoiling by topoisomerase enzymes; discovery of extended-assortment conformational adjustments in Mre11/DNA fix complexes; and very first pressure measurements on a DNA molecule inside of a nanopore
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and one-molecule experiments